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Mammary Neoplasia in Sprague-Dawley or Long-Evans Rats after in Vitro 7, 12-Dimethylbenz() anthracene¹

Medical Department, Brookhaven National Laboratory Associated Universities, Inc., Upton, Long Island, New York 11973

Long-Evans female rats show a smaller mammary neoplastic response than do Sprague-Dawley females to 7,12-dimethylbenz()anthracene (DMBA) applied directly to mammary tissue in vitro when the excised mammary tissue is grafted back into the animal from which it came. Long-Evans rats also give a smaller mammary neoplastic response to DMBA administrated by stomach tube. It was suggested that the difference in the mammary neoplastic response to DMBA observed in the 2 strains depends upon strain differences that act after the initial DMBA-mammary tissue interaction.

¹ Brookhaven National Laboratory is supported by the United States Atomic Energy Commission Research, supported in part by the USPHS Grant 5T01 CA05243.

² Deceased.

Received 4/18/74. Accepted 7/ 1/74.