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Heterotopic Urinary Bladders in Rats Produced by an Isograft Inoculum of Bladder Fragments and Air¹

Cancer Bioassay Laboratory, Department of Pathology, The Medical College of Pennsylvania, Philadelphia, Pennsylvania 19129

A pseudobladder is formed by inoculating rats s.c. with a combination of rat bladder fragments and air. Within 1 month a cyst is produced that is lined completely by normal-appearing urothelium. The heterotopic pseudobladder persists for as long as 6 months. In some 6-month-old bladder walls, foci of bone formation are found in the stroma underlying the urothelium. The lining epithelium at all stages from 1 to 6 months is characteristic of normal urothelium by light and electron microscopic criteria.

¹ Supported by Research Grant CA 14137 from the National Cancer Institute. Reprint requests to any of the authors should be addressed to Cancer Bioassay Laboratory, Department of Pathology, The Medical College of Pennsylvania, 3300 Henry Avenue, Philadelphia, Pa. 19129.

² Presented April 29, 1974, to Delta Chapter, Alpha Omega Alpha, National Medical Honor Society.

³ Institute for Environmental Medicine, New York University Medical Center, New York, N. Y.

Received 4/22/74. Accepted 7/ 3/74.

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