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Glutamate Dehydrogenase Activity Related to Histopathological Grade of Hepatocellular Carcinoma in Man¹

Departments of Pharmacology [R. I. G.] and Medicine [C. L. V.], Emory University, Atlanta, Georgia 30303; Solid Tumor Center, Uganda Cancer Institute, Kampala, Uganda [I. R. P.]; and The Bland-Sutton Institute of Pathology, The Middlesex Hospital Medical School, London, England [P. P. A.]

The activity of glutamate dehydrogenase (L-glutamate: nicotinamide adenine dinucleotide oxidoreductase (deaminating, EC 1.4.1.3) was measured in nonneoplastic liver and tumor tissue obtained by biopsy of Ugandan patients with primary hepatocellular carcinoma. A proportionality was found between decreased glutamate dehydrogenase activity and decreased histological differentiation of the hepatoma. Analyses of serum levels of -fetoprotein also suggested a correlation between the amount of biochemical marker and the histopathological grade of the carcinoma. Other serum enzymes, such as protocollagen proline hydroxylase, serum glutamic-oxalacetic transaminase, and alkaline phosphatase were elevated in most patients with primary hepatocellular carcinoma, irrespective of the grade of the tumor.

¹ This work was supported in part by Contract PH 43-67-1343 from the National Cancer Institute, Bethesda, Md.

² To whom reprint requests should be addressed, at Emory University School of Medicine, Glenn Building, 69 Butler Street, SE, Atlanta, Ga. 30303.

Received 5/20/74. Accepted 7/23/74.