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Cytoplasmic Alterations of Hepatocytes in Rainbow Trout (Salmo gairdneri) Induced by Cyclopropenoid Fatty Acids¹

Department of Pathology and Oncology, University of Kansas Medical Center, Kansas City, Kansas 66103 [D. G. S., M. C.] and Department of Food Science and Technology, Oregon State University, Corvallis, Oregon 97331 [D. J. L., R. O. S.]

Rainbow trout were fed a diet containing 200 ppm of the cyclopropenoid fatty acids, sterculic and malvalic acids, substances that greatly increase the sensitivity of trout liver cells to the carcinogenic effects of aflatoxin B₁. After 4 weeks, peculiar cleft-like striations appeared in the cytoplasm of hepatocytes. These alterations became progressively more frequent and marked with continued feeding of the diet. At 8 and 12 weeks, the rough-surfaced endoplasmic reticulum contained many parallel arrays and whorled profiles of membrane material. Concomitant with the development of these cytoplasmic alterations, the activity of glucose 6-phosphatase in liver was decreased significantly and remained thus as long as cyclopropenoid fatty acids feeding was continued. On the other hand, the ability of trout liver to o-dealkylate phenacetin remained unchanged. These results suggest that the effect of cyclopropenoid fatty acids on the endoplasmic reticulum is limited to the rough-surfaced variety.

¹ These studies were supported in part by USPHS Grants CA 10257, ES 00263, and ES 00256.

Received 1/29/74. Accepted 7/30/74.

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