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Respiratory Tract Tumors in Hamsters Induced by Benzo(a)pyrene and ²¹⁰Po -Radiation¹

Department of Physiology, Harvard University School of Public Health, Boston, Massachusetts 02115

A high incidence of respiratory cancer has been induced in Syrian golden hamsters by repeated intratracheal instillations of either benzo(a)pyrene or ²¹⁰Po adsorbed onto hematite carrier particles. Both the tumor incidence and the mean induction time were related to the dose of carcinogen. Benzo(a)pyrene induced a spectrum of tumors, among which, the types occurring most frequently were epidermoid carcinomas of the trachea or major bronchi. ²¹⁰Po-induced tumors were almost exclusively combined epidermoid and adenocarcinomas that arose peripherally; these tumors occurred in 94% of animals in the highest exposure group. Hamsters appear particularly susceptible to the induction of lung cancer by -radiation at doses that do not produce concomitant lung damage, and they may provide a good model for the study of interactions between radiation and chemical agents in respiratory carcinogenesis.

¹ Supported by Grant P-613 from The American Cancer Society, Grant 1345-C-1 from The American Cancer Society (Massachusetts Division), and Grant ES-00002 from the NIH.

Received 4/15/74. Accepted 8/ 7/74.

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