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Primary Granulocytic Leukemia in the Rat

Department of Medicine, Peter Bent Brigham Hospital, and Children's Cancer Research Foundation, Harvard Medical School, Boston, Massachusetts 02115

Granulocytic leukemia is a rare disease in the rat; it seldom occurs spontaneously although chemical agents and ionizing radiation may increase the incidence in some rat strains. The disease resembles granulocytic leukemia in man and the leukemic cells possess a number of interesting enzymatic and other features. Granulocytic leukemia is readily transplantable and the leukemic cells grow well in vitro. This disease presents an excellent opportunity for investigation of granulocytic proliferation and differentiation; it may provide a unique test system for evaluation of chemotherapy and immunotherapy and serve as an animal model for acute granulocytic leukemia in man.

¹ This work was supported by the American Cancer Society (Massachusetts Division) Grant 972C-1, American Cancer Society (National) Grant CY-4724, USPHS Grants CA 05691-05 and CA-10941, and the Nehemias Gorin Foundation.

Received 8/24/72. Accepted 6/28/74.