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A Population Screening for Fetal Sulfoglycoprotein Antigen in Gastric Juice¹

Department of Pathology, University of Turku, and The Laboratory of the Cancer Society of Southwestern Finland, Turku, 52, Finland

Results of 3 population studies in age groups 40 to 65, 2 of them in an industrial population and 1 among unselected rural population are presented. Altogether, approximately 14,000 people participated. Fetal sulfoglycoprotein antigen was found in gastric juice in about 3% of the industrial and 5 to 7% of the rural population. Three histologically verified cases and 1 suspected case of gastric cancer, all clinically symptomless, were found among the Fetal sulfoglycoprotein antigen-positive cases. In addition, there was 1 case of gastric polyposis. All of them underwent radical surgery. In the follow-up since 1970, no new case of clinical gastric cancer has appeared among the Fetal sulfoglycoprotein antigen-negative persons in the study. The possibility of using this screening method for early detection of gastric cancer on a large scale is discussed.

¹ This research was supported by grants from the Finnish Medical Research Council and the J. K. Paasikivi Foundation, and by a research contract with the Finnish Cancer Society.

Received 2/ 7/74. Accepted 7/ 2/74.