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A Difference between B10.D2/n and B10.D2/o Strains of Mice in Rates of Irradiation-induced Leukemogenesis

The Jackson Laboratory,^,4 Bar Harbor, Maine 04609 [N. K., H. M., S. H. L.], and the Department of Microbiology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205 [H. S. S.]

Mice of the congenic strains B10.D2/n and B10.D2/o develop lymphoid leukemia after exposure to X-irradiation. In three of four trials, leukemogenesis rates were significantly higher in B10.D2/n females than in B10.D2/o females. B10.D2/o mice lack complement component C5; B10.D2/n are normal for complement. Spleens of young females of both strains were negative for type C RNA virus gs-antigen. In contrast, most spleens of leukemic mice were gs-antigen positive. All virus isolates were B-trop; i.e., they grew on BALB/c embryo fibroblast cultures but not on SWR embryo cells.

¹ Supported by NIH Grant 5 S01 RR05545 and NIH Research Grant CA 01594 from the National Cancer Institute, and in part by a grant from the Eva Gebhard-Gourgaud Foundation.

² Supported by Research Contract N01 CP 33255 within the Special Virus-Cancer Program of the National Cancer Institute.

³ Supported by NIH Research Grant 1 R01 CA 14113 from the National Cancer Institute and American Cancer Society Grant IC-87. Recipient of NIH Career Development Award 5 K4-GM-50, 193.

⁴ The Jackson Laboratory is fully accredited by the American Association for Accreditation of Laboratory Animal Care.

Received 4/25/74. Accepted 8/12/74.