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Potentiation of Bleomycin by an Antifungal Polyene, Pentamycin, in Transformed Animal Cells¹

Cancer Research Institute [T. N., M. K., K. M., H. E.] and Department of Otorhinolaryngology [S. K., I. H.], Faculty of Medicine, Kyushu University, Fukuoka 812, Japan

Bleomycin, a potent antitumor agent against human squamous cell carcinoma, was examined in vitro to determine whether its action is increased under synergistic conditions with a polyene antibiotic, pentamycin. The inhibition of DNA, RNA, and protein synthesis by bleomycin was greatly enhanced by combination with pentamycin in tissue culture. However, in comparison with bleomycin or -amanitin, there was less enhancement of action of both 5-fluorouracil and fusidic acid by pentamycin.

¹ Supported by a Grant-in-Aid for scientific research from the Ministry of Education, Japan.

² To whom requests for reprints should be sent.

Received 4/16/74. Accepted 7/ 8/74.