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Tumor Regression and Enhancement Resulting from Immunotherapy with Bacillus Calmette-Guérin and Neuraminidase¹

Experimental Immunotherapy Laboratory, Sepulveda Veterans Administration Hospital, Los Angeles, California 91343 [F. C. S., J. B.], and the Division of Oncology, Department of Surgery, University of California, Los Angeles, California 90024 [F. C. S.]

The effect of Bacillus Calmette-Guérin (BCG) and/or neuraminidase (VCN) on tumor growth was studied in four murine fibrosarcomas. In the first tumor system, the intratumor injection of BCG resulted in increased tumor growth of both injected and uninjected tumors. In the second tumor system, the intratumor injection of BCG and VCN resulted in earlier growth of both injected and distant uninjected tumors. In the third tumor system, immunoprophylaxis with BCG made mice more resistant to subsequent challenge with tumor cells, and the intratumor injection of BCG, VCN, or BCG and VCN resulted in complete regression of established tumors. In the fourth tumor system, BCG, injected into the tumor or into a distant site, and the combination of BCG and VCN, injected into either the tumor or into the site of subclinical foci of tumor, caused increased tumor growth.

¹ Supported by grants from the Veterans Administration and the California Institute of Cancer Research.

Received 5/20/74. Accepted 8/14/74.