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Carcinofetal Human Isoferritins in Placenta and HeLa Cells¹

Department of Biochemistry and Pharmacology and Cancer Research Center, Tufts University School of Medicine, Boston, Massachusetts 02111

Ferritins from normal liver, placenta, and HeLa cells were resolved into their constituent isoferritins by gel electrofocusing. HeLa cells gave only two isoferritins. These isoferritins were not detected in liver. Placenta and liver each contained about six isoferritins with several in common. In addition, placenta contained two isoferritins that appeared to correspond to the HeLa isoferritins. Both of the carcinofetal forms in placenta and HeLa cells were recognized by antibodies prepared against normal adult liver ferritin.

¹ This work was supported by Grants AM 16781 and CA 14406 and 12924.

² To whom reprint requests may be addressed.

Received 3/11/74. Accepted 8/28/74.

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