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Tumor Induction in the Progeny of Mice Receiving 4-Nitroquinoline 1-Oxide and N-Methyl-N-nitrosourethan during Pregnancy or Lactation¹

First Department of Surgery [T. N., E. O., H. M.], and Institute for Cancer Research [T. N., N. T., S. K., Y. I., Y. S.], Osaka University Medical School, Dôjima-hamadôri 3-12, Fukushima-ku, Osaka 553, Japan

Pregnant mice were given s.c. injections of 4-nitroquinoline 1-oxide once only on Day 9, 13, or 17 or of N-methyl-N-nitrosourethan on Day 9, 11, 13, 15, or 17. Offspring of mice that received 4-nitroquinoline 1-oxide on Day 13 or 17 developed lung tumors in significantly high incidence, and offspring of those treated on Day 9 bore some malformations. However, tumors were not observed in the offspring when N-methyl-N-nitrosourethan was given on Day 11 or later, although lung tumors and malformations were induced when it was given on Day 9. When 4-nitroquinoline 1-oxide was given to lactating mice, their sucklings developed lung tumors and hepatomas.

¹ This investigation was presented at the 6th Annual Meeting of the Japanese Society of Pediatric Surgery (1969), Sendai, Japan, and at the 32nd Annual Meeting of the Japanese Cancer Association (1973), Tokyo, Japan. This work was supported by grants from the Japanese Ministry of Education, Japanese Ministry of Health and Welfare, Osaka Taigan-Kyokai, Osaka, Japan, and Shôni-no-Gan-o-Mamoru-kai, Tokyo, Japan.

² Present address: First Department of Surgery, Hyogo College of Medicine, Nishinomiya, Hyogo-ken, Japan.

Received 12/ 3/73. Accepted 8/16/74.