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The Inhibitory Effects of -Benzene Hexachloride on 3'-Methyl-4-dimethylaminoazobenzene and DL-Ethionine Carcinogenesis in Rats¹

Department of Pathobiology, Faculty of Science, Rama VI Road, Bangkok 4, [W. T., N. B.], Thailand and Department of Pathology [Y. H.] and Cancer Institute [N. I.], Nara Medical University, Nara 634, Japan

This study was on the inhibitory effects of 0.06% -benzene hexachloride (-BHC) on hepatic changes including development of hepatoma in rats induced by 0.06% 3'-methyl-4-dimethylaminoazobenzene (3'-Me-DAB) or 0.25% DL-ethionine.

-BHC inhibited the induction of hepatocellular carcinoma in rats treated with 3'-Me-DAB for 5 months or with ethionine for 4.5 months.

-BHC inhibited the induction of nodular hyperplasia in rats treated with 3'-Me-DAB for 2 months or with DL-ethionine for 4.5 months but did not inhibit the induction of nodular hyperplasia in rats treated with 3'-Me-DAB for 5 months.

In addition, -BHC inhibited the occurrence of oval cell infiltration and caused the increase in liver weight in proportion to body weight in rats treated with 3'-Me-DAB or DL-ethionine for 2 months.

¹ This investigation was supported by the Faculty of Graduate Studies of Mahidol University, Bangkok, Thailand. A part of this work was submitted by Dr. Thamavit in partial fulfillment for the requirement for a Master of Science degree in Experimental Pathology at Mahidol University.

Received 7/12/73. Accepted 11/13/73.