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Lack of Syncytium Formation by a Type C Virus-producing XC Cell Line in the Mixed Culture Cytopathogenicity Test¹

Department of Virology, The University of Texas System Cancer Center, M. D. Anderson Hospital and Tumor Institute, Texas Medical Center, Houston, Texas 77025

XC cells, derived from a Rous sarcoma virus-induced Wistar strain rat tumor, form syncytia when cultured in the presence of murine leukemia virus-producing mouse cells. However, one XC cell culture (designated as XC-v cells), found to produce type C virus particles, fails to form syncytia in the presence of murine leukemia virus-producing mouse cells. Coculture of XC-v cells and XC cells negative for type C virus particles leads to a moderate degree of syncytium formation. Infection of XC cells with either the Moloney (M) strain of mouse leukemia virus or type C virus particles released by XC-v cells results in the loss of ability of XC cells to form syncytia in the mixed culture cytopathogenicity test. The syncytium-forming ability of XC cells, therefore, is altered by the presence of a type C virus in these cells.

¹ This work was supported in part by USPHS Contract NO1-CP-33304 within the Virus Cancer Porgram of the National Cancer Institute and by Grant CA-05831 from the National Cancer Institute, NIH.

² To whom requests for reprints should be addressed.

Received 8/ 6/73. Accepted 11/21/73.