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Effect of Antiserum to Human Chorionic Gonadotropin on Growth and Function of Choriocarcinoma in Vivo and in Vitro

Reproduction Research Branch, National Institute of Child Health and Human Development, NIH, Bethesda, Maryland 20014

The effects of antiserum to human chorionic gonadotropin (HCG) on growth and endocrine function of human choriocarcinoma serially transplanted in the cheek pouch of the hamster and maintained in tissue culture were examined. Anti-HCG serum given in amounts sufficient to neutralize the biological effect of the HCG secreted by the tumor significantly reduced tumor size. Since tumor growth was not enhanced by HCG administration or by ovariectomy, the antitumor effect could not be attributed to neutralization of the hormonal effects of the HCG. Anti-HCG serum had no effect on the growth of choriocarcinoma cells in vitro, suggesting that a host factor was required for the in vivo effect of the antiserum on tumor growth.

Received 9/ 4/73. Accepted 11/28/73.