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Increased Incidence of Placenta-like Alkaline Phosphatase Activity in Breast and Genitourinary Cancer¹

Department of Clinical Biochemistry, Sunnybrook Hospital, University of Toronto, Toronto, Canada M4N 3M5

The incidence of placenta-like alkaline phosphatase activity in serum was investigated in patients with diagnosed active malignant disease, in patients with a variety of nonmalignant conditions, and in normal individuals. The increased occurrence of this isoenzyme in cancer was not great enough to provide the basis for a useful diagnostic screening test. However, significant association of placenta-like alkaline phosphatase activity in the serum of patients with tumors of the female breast and genitourinary tract was noted and suggests that the test may be useful in these conditions as an indicator of disease activity.

¹ This work was supported by Ontario Cancer Treatment and Research Foundation Grant 260.

² Present address: Department of Chemistry, St. John Regional Laboratory, Saint John, New Brunswick, Canada.

³ Present address: Department of Medicine, Mount Sinai Hospital, 550 University Avenue, Toronto, Ontario, Canada.

Received 9/ 5/73. Accepted 12/31/73.