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Strain- and Age-dependent Transplacental Carcinogenesis by 1-Ethyl-1-nitrosourea in Inbred Strains of Mice¹

The Jackson Laboratory, Bar Harbor, Maine 04609

Pregnant AKR/J, SWR/J, DBA/2J, C57BL/6J, and C57L/J mice were given a single i.p. injection of ENU, 0.5 mmole/kg, in trioctanoin on either Day 12, 14, 16, or 18 of gestation. Tumors developed in offspring of all strains, but the incidence, type, and latency period depended on both the inbred strain and the specific day of gestation. The most common tumors were single or multiple pulmonary adenomas and leukemias after exposure to ENU on Days 16 and 18, respectively. These two types of tumor were frequently concurrent, but each was found simultaneously with other tumor types as well. Aside from thymic or splenic leukemias and pulmonary adenomas, other tumor types were hepatomas, Harderian gland adenomas, tumors of endocrine glands, particularly the ovary, and even neurogenic tumors. Hepatomas occurred preferentially in males, and certain tumors appeared more frequently in some strains than in others.

¹ This study was supported by NIH Training Grant CA 05013 from the National Cancer Institute to The Jackson Laboratory, and by Research Contract N01 CP 33255 within the Special Virus-Cancer Program of the National Cancer Institute. The Jackson Laboratory is fully accredited by the American Association for Accreditation of Laboratory Animal Care.

Received 6/15/73. Accepted 12/21/73.