This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Bhuyan, B. K. Articles by Fraser, T. J. Search for Related Content PubMed PubMed Citation Articles by Bhuyan, B. K. Articles by Fraser, T. J.

Antagonism between DNA Synthesis Inhibitors and Protein Synthesis Inhibitors in Mammalian Cell Cultures¹

Cancer Research, The Upjohn Company, Kalamazoo, Michigan 49001

Streptovitacin A (a protein synthesis inhibitor) partially protected DON cells from the lethality of 1-ß-D-arabinofuranosylcytosine (cytarabine), hydroxyurea, and 5-hydroxy-2-formylpyridine thiosemicarbazone (DNA synthesis inhibitors and S-phase-specific agents). Our results suggest that the cells in S were not protected by streptovitacin A while the non-S-phase cells were protected.

¹ This investigation was supported in part by Contract PH43-NCI-68-1023 Division of Cancer Treatment, National Cancer Institute, NIH, Department of Health, Education and Welfare.

Received 4/23/73. Accepted 12/26/73.

This article has been cited by other articles:

				M. McGahren-Murray, N. H.A. Terry, and K. Keyomarsi The Differential Staurosporine-Mediated G1 Arrest in Normal versus Tumor Cells Is Dependent on the Retinoblastoma Protein Cancer Res., October 1, 2006; 66(19): 9744 - 9753. [Abstract] [Full Text] [PDF]