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Biochemical Approaches to Detection of Herpes Simplex Virus Type 2 in Cervical Carcinoma¹

BioLabs, Inc., Northbrook, Illinois 60062

Nucleic acid hybridization techniques are highly sensitive methods for determining the presence of herpes simplex type 2 genomes. Measurement of the rate of reassociation between labeled, purified viral DNA and DNA extracted from the tumor cells may be necessary to achieve adequate sensitivity if only a portion of the viral genome is present and if tumors contain substantial proportions of cells other than tumor cells. A large number of cervical tumors in various stages, as well as many control tissues, need to be studied to permit a decision on the involvement of herpesvirus type 2 in causing cervical carcinoma.

¹ Presented at the International Symposium on Human Tumors Associated with Herpesviruses, March 26 to 28, 1973, Bethesda, Md. Supported in part by Contract NIH-NCI-72-2068 within the Virus Cancer Program of the National Cancer Institute, USPHS.