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The Hamster as a Host for the Growth and Study of Human Tumor Cell Populations¹

Department of Functional Pathology, Chester Beatty Research Institute, London SW3 UJB, England

This work describes the extent to which a variety of human tumors became established and proliferated s.c. in the immune-deprived hamster. Immune deprivation was accomplished by thymectomy at 2 weeks of age and treatment for 3 weeks with rabbit anti-hamster thymocyte serum.

Four hundred fifty-seven hamsters were given implants of tumor from 77 patients. The tumors arose from 18 types of tissue. Tumor from 11 patients grew to overwhelm the animal and in some cases showed infiltration of host tissues and metastasis. More limited growth was observed in tumors from 27 patients. The most successful growth was observed with carcinomas of the colon, rectum, ovary, breast, kidney, and bronchus.

¹ Supported by grants made to the Chester Beatty Research Institute from the Medical Research Council and the Cancer Research Campaign.

² Present address: Huntingdon Research Centre, Huntingdon PE18 6ES, England.

Received 10/23/73. Accepted 1/18/74.