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The Action of Nitrogen Mustard in Synchronized Intestinal Crypt Cells in Vivo¹

Departments of Pathology, University of Pittsburgh Schools of Medicine and Dental Medicine, Pittsburgh, Pennsylvania 15261

The exposure to nitrogen mustard of synchronized crypt epithelial cells during various stages of the proliferative cycle induced distinctive morphological alterations in the intestinal mucosa. These structural abberrations were virtually identical regardless of the position of the crypt epithelial cells within the generation cycle at the time of drug administration and were indistinguishable from those induced in asynchronous populations. These findings indicate that nitrogen mustard can exert its cytotoxic effects not only throughout interphase but during the stage of nuclear division as well.

¹ This research was supported by Grant CA-11390 from the National Cancer Institute.

² Present address: Fels Research Institute, Temple University School of Medicine, Philadelphia, Pa. 19140.

Received 9/21/73. Accepted 3/ 5/74.