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Isolation of a Transplantable Cell Line Induced by the MC29 Avian Leukosis Virus¹

Department of Surgery, Duke University Medical Center, Durham, North Carolina 27710

A transplantable cell line was isolated from a liver tumor induced by the MC29 strain of avian leukosis virus. It was found that its ability to develop into a tumor when inoculated in recipient birds (both intramuscularly and in the wing web) was dependent on a morphological alteration which took place after the cells had been in culture for some time. The transplantable cell exhibited unusual properties, compared with other MC29 altered cells, and appears to represent a unique target cell for the MC29 virus.

¹ This work was supported by Contracts NIH-71-2132 and N01 CP 33308 from The Virus Cancer Program of the National Cancer Institute.

² Present address: First Institute of Pathology, Medical University of Budapest Budapest, 8, Hungary.

³ Present address: Life Sciences, Inc., St. Petersburg, Fla. 33710.

Received 11/ 1/73. Accepted 3/12/74.

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