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Prolonged Survival in Long-Passage AKR Leukemia Using Chemotherapy, Radiotherapy, and Adoptive Immunotherapy¹

The May and Sigmund Winter Research Laboratory, Mount Sinai Medical Center [M. M. B., A. A. R., R. H. G., E. C. S.]; The Milwaukee Blood Center [G. E. R.]; and the Departments of Medicine [M. M. B., G. E. R.], Biostatistics [A. A. R.], and Surgery [E. C. S.], Medical College of Wisconsin, Milwaukee, Wisconsin 53233

A chemoradioimmunotherapeutic model, with potential for clinical applicability, was tested in AKR mice bearing a long-passage lymphocytic leukemia. A temporary graft-versus-leukemia reaction was the key feature of the model. In the most successful experimental groups, graft-versus-host disease was circumvented and "cell cure" of a transplanted acute lymphocytic leukemia was achieved in at least 88% of the mice. Late mortality occurred in 58% of these mice and was due mainly to bone marrow and lymphoid aplasia of unknown cause. Appearance of spontaneous leukemia-lymphoma was significantly delayed or prevented in those mice that survived the first 100 days, and 20% lived beyond 21 months of age.

¹ Presented in part at the Second Annual Conference of the International Society for Experimental Hematology, Paris, France, June 25 to 27, 1973. Research supported by American Cancer Society Grant ET-55; a grant from the Board of Trustees, Mount Sinai Medical Center; a memorial to William Heller, Sr.; Grant HE 13-629 from the National Heart and Lung Institute; and a grant from the Milwaukee Division of the American Cancer Society. This is Paper 4 in a series titled "Graft-versus-Leukemia."

² To whom reprint requests should be addressed, at the Winter Research Laboratory, Mount Sinai Medical Center, 948 North 12th Street, Milwaukee, Wis. 53233.

³ Special Fellow, Winter Research Laboratory, Mount Sinai Medical Center, 1972.

Received 12/26/73. Accepted 4/22/74.