This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Mohr, J. A. Articles by Coalson, J. J. Search for Related Content PubMed PubMed Citation Articles by Mohr, J. A. Articles by Coalson, J. J.

Alveolar Cell Carcinoma-like Antigen and Antibodies in Patients with Alveolar Cell Carcinoma and Other Cancers¹

Departments of Medicine [J. A. M., E. R. R.], Microbiology, [J. A. M., E. R. R.], Immunology [J. A. M.], Anatomical Sciences [R. E. C.] and Pathology [J. J. C.], University of Oklahoma Health Sciences Center, and Department of Experimental Pathology, Oklahoma Medical Research Foundation[R. E. N.], Oklahoma City, Oklahoma 73104

Antiserum was produced in sheep against a particle pellet recovered from human alveolar cell carcinoma (ACC). The antiserum was used for the detection of similar antigens in patients with ACC using the immunodiffusion method. Tumor cell lines were used in the indirect fluorescent technique for the detection of antibodies in the serum of patients with tumors and control serum. The results indicate that similar antigens are present in the serum of some patients with ACC, primary adenocarcinoma of the lung, and Hodgkin's disease. Antibodies develop in some patients with ACC and primary adenocarcinoma of the lung and in sheep inoculated with the agent.

¹ This research was supported in part by funds from NIH Grant CA 12129-01, VA Hospital Oklahoma City, Oklahoma Lung Research and Development Program.

Received 9/20/73. Accepted 4/10/74.