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⁶⁷Ga Binding to Human Serum Proteins and Tumor Components

Institute of Neurochemistry, 71 Rådmandsgade, DK-2200 Copenhagen N [J. C.], and Department of Nuclear Medicine, Rigshospitalet, 9 Blegdamsvej, DK-2100 Copenhagen Ø [C. J. E., J. F.], Denmark

⁶⁷Ga is known to concentrate in a variety of malignant tumors. Immunoelectrophoresis combined with autoradiography of human serum incubated with ⁶⁷Ga showed that the radionuclide is associated with transferrin, apart from a weak binding to ß-lipoprotein. The thermodynamic constant for gallium was estimated and indicated that gallium citrate in the presence of serum proteins occurred in a colloid form bound to transferrin.

Ultracentrifugation of tumor homogenates obtained from patients who had received i.v. injections of ⁶⁷Ga citrate for scintigraphy demonstrated that ⁶⁷Ga is preferentially bound to proteins in the nuclei fraction. Acrylamide gel electrophoresis of extracts of cancer tissue indicated that intracellular ⁶⁷Ga is associated mainly with a fast-migrating substance, perhaps a protein, with a molecular weight lower than that of ferritin.

Received 7/13/73. Accepted 4/ 2/74.

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