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Enhancement of 7,12-Dimethylbenzanthracene Skin Carcinogenesis by Adenosine 3',5'-Cyclic Monophosphate¹

The Eppley Institute for Research in Cancer, University of Nebraska Medical Center, Omaha, Nebraska 68105

Adenosine 3',5'-cyclic monophosphate was injected i.p. into strain A mice receiving the chemical carcinogen 7,12-dimethylbenzanthracene topically on the interscapular area of the skin. Adenosine 3',5'-cyclic monophosphate increased the incidence of skin papillomas and squamous cell carcinomas in the 7,12-dimethylbenzanthracene-treated mice whereas 5'-adenosine monophosphate, the immediate metabolite of adenosine 3',5'-cyclic monophosphate, had no effect on the incidence of tumors in 7,12-dimethylbenzanthracene-treated mice.

¹ This work was supported by American Cancer Society Grant BC-48A and National Cancer Institute Contract PH43-68-959.

² Recipient of USPHS Postdoctoral Fellowship CA05220.

Received 2/19/74. Accepted 5/10/74.