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Cytofluorescence Localization of Adriamycin and Daunorubicin

Baltimore Cancer Research Center, National Cancer Institute, NIH, Baltimore, Maryland 21211

The characteristic orange-red fluorescence of adriamycin or daunorubicin is easily detectable in tissues of drug-treated hamsters when examined by fluorescence microscopy. Fluorescence was seen intracellularly as early as 0.5 min postinjection. Drug fluorescence was localized primarily in nuclei although some cytoplasmic drug fluorescence was detected in liver and kidney cells. No difference between adriamycin and daunorubicin was observed with this technique.

¹ To whom requests for reprints should be addressed.

Received 12/26/73. Accepted 5/20/74.

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