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The Effect of 6-Mercaptopurine and Allopurinol on Granulopoiesis¹

The Edward Mallinckrodt Department of Pediatrics, Washington University, Division of Hematology and Oncology, St. Louis Children's Hospital, St. Louis, Missouri 63110

The effect on granulopoiesis of 6-mercaptopurine alone, and in combination with allopurinol, was studied in mice using an in vitro colony-forming assay for granulocytic progenitor cells. The combination of 6-mercaptopurine and allopurinol produced significantly greater suppression of de novo granulopoiesis than did 6-mercaptopurine alone. Allopurinol in very high doses was found to be myelosuppressive. The possible implications of these findings are discussed.

¹ Supported in part by NIH Grant 5R10 CA 05587-14 and by the Children's Hematology Research Association of St. Louis.

² To whom reprint requests should be addressed, at Department of Pediatrics, St. Louis Children's Hospital, 500 S. Kingshighway, St. Louis, Mo. 63110.

Received 3/ 1/74. Accepted 5/20/74.