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Lack of Increased Differentiation of Leukemic Cells in Response to Colony-stimulating Factor¹

Department of Medicine, University of Adelaide, Royal Adelaide Hospital, Adelaide, Australia

Cells from 11 patients with acute myeloid or myelomonocytic leukemia were exposed to high and low concentrations of colony-stimulating factor by culturing them on basal layers that did or did not contain normal leukocytes, by culturing at high or low cell concentrations, and by adding colony-stimulating factor to the cultures. The degree of differentiation was assessed morphologically. There was no significant difference in the degree of differentiation produced by these experimental manipulations, suggesting that the colony-stimulating factor has relatively little influence on leukemic cell differentiation.

¹ This work was supported by The Michell and Anti-Cancer Foundations of the University of Adelaide and the National Health and Medical Research Council of Australia.

Received 7/24/73. Accepted 5/23/74.

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