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Further Studies on Mouse Fetal Antigen Cross-reactive with Rauscher Leukemia¹

Laboratory of Viral Oncology, Research Institute, Aichi Cancer Center, Nagoya, 464 Japan

The time course for the appearance of the cell surface antigen in the embryo cross-reactive with Rauscher leukemia was examined. The antigen detectable by test serum first appeared in 12-day-old embryos and continued to be demonstrable until the day of birth. The antigen was abundant in the cells from the digestive tract, but not in the cells from the liver and brain. A natural antibody reactive to mouse fetal antigen(s) was shown to exist in the sera of a few C57BL/6 mice of both sexes older than 8 months. The antibody cross-reactive with Raucher leukemia cells and embryonic cells was clearly differentiated from the IgM autoantibody in mouse alloantisera.

¹ This work was supported in part by Grants-in-Aid for Scientific Research 801002, 801030, and 801057 from the Ministry of Education, Government of Japan, and by Contract NOI-CP-33290 from the National Cancer Institute within the Virus Cancer Program.

² Present address: Department of Microbiology, Faculty of Medicine, Kyoto University, 606 Sakyo-ku, Kyoto, Japan.

Received 12/27/73. Accepted 4/30/74.