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Vascular Changes in Neuroblastoma of Mice following X-irradiation¹

Departments of Therapeutic Radiology [C. W. S., J. J. C., S. H. L.] and Neurology [J. H. S.], University of Minnesota Medical School, Minneapolis, Minnesota 55455

Vascular changes in a transplantable neuroblastoma of A/J mice following X-irradiation were studied. X-irradiation with doses lower than 500 rads in a single exposure caused a slight increase in the functional intravascular volume, as measured with ⁵¹Cr-labeled red cells 1 day after the irradiation, and a gradual decrease thereafter. X-irradiation with 1000 and 2000 rads, in contrast, induced a decrease in the vascular volume at 1 day postirradiation and a further gradual decrease thereafter. The extravasation of plasma protein, as measured with ¹²⁵I-labeled plasma protein, increased soon after irradiation with doses of 250 to 2000 rads, and then decreased. Histopathological studies of tumors irradiated with 2000 rads revealed a progressive crowding or condensation of the vascular bed as the tumor cell population became reduced or tumor lobules receded. Direct irradiation-induced damage to the vessels and the disorganization of the architecture of vascular networks following irradiation appear to cause vascular occlusion and interfere with the blood flow in the tumors.

¹ This work was supported by USPHS Grants CA13353 and CA08832.

Received 2/11/74. Accepted 5/15/74.

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