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Transplantation of Hepatomas Induced in the Avian Liver by MC29 Leukosis Virus¹

First Institute of Pathology, Semmelweis Medical University, Budapest, Hungary [K. L.], and Department of Surgery, Duke University Medical Center, Durham, North Carolina 27706 [D. B., J. W. B.]

A hepatomatous growth derived from primary liver tumors induced in chickens by i.v. inoculation with MC29 leukosis virus has been established and maintained in the avian host. Hepatoma tissue transplanted into the abdominal cavity in a total of 278 chicks in 35 experiments yielded tumors in 222 animals (80%). The i.m. implantation in 69 birds in 7 experiments resulted in growth in 67 chicks (97%). Tumor tissue introduced inadvertently into the s.c. tissue likewise grew very rapidly. Histological and cytological features of the transplants in all sites showed preservation of the morphological characteristics of the original primary liver tumors through repeated passages. The properties of this first transplantable hepatoma derived from virus-induced primary liver tumors are compared with those of other transplantable hepatomas.

¹ This work was supported in part by USPHS Research Grant C-4572; by Contracts NIH-71-2132 and NOI-CP-33291 within the Virus Cancer Program of the National Cancer Institute. NIH, USPHS; and by the Dorothy Beard Research Fund.

² Present address: Life Sciences Research Laboratories, St. Petersburg, Fla. 33710.

³ To whom requests for reprints may be addressed, at the Life Sciences Research Laboratories.

Received 6/27/74. Accepted 9/13/74.