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The Effect of Nephrectomy on the Incidence of Breast Carcinoma in Irradiated Parabiosed Rats¹

Cancer Research Institute, New England Deaconess Hospital, Boston, Massachusetts 02215

The incidence of carcinoma of the breast in parabiosed female NEDH rats is 2.5%. When one member of such a pair is irradiated, the incidence rises to 11% in the irradiated partner and 10% in the nonirradiated partner. If in such a pair of rats one kidney is removed from each partner, the incidence of breast carcinoma rises fivefold in the nonirradiated partner. The factors involved in such an increase probably have to do with alteration in retention, interchange, and feedback of the pituitary and ovarian hormones.

¹ This investigation was supported by United States Atomic Energy Commission Contract AT(11-1)-3017 with the New England Deaconess Hospital and by USPHS Grant RR 05591 from the General Research Support Branch, Division of Research Resources. The research described in the report involved animals maintained in animal care facilities fully accredited by the American Association for Accreditation of Laboratory Animal Care. We are indebted to the National Institute of Arthritis, Metabolism and Digestive Diseases Rat Pituitary Distribution Program for reagents and methods for the rat FSH and prolactin studies.

Received 5/ 1/74. Accepted 10/ 1/74.