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Decreased Lymphocyte Adenosine Deaminase Activity in Acute Lymphocytic Leukemic Children and Their Parents¹

The Department of Biochemistry, Wayne State University School of Medicine, Detroit, Michigan 48201 [J. Z., J. J. L.], and Child Research Center, Childrens Hospital, Detroit, Michigan 48201 [A. S. K.]

Adenosine deaminase has been measured in the lymphocytes of children with acute lymphocytic leukemia and in those of their parents. The activity was found to be significantly lower in both acute lymphocytic leukemia children in remission and relapse and in the parents of acute lymphocytic leukemia children when compared with normal adults and children of similar ages.

¹ Supported by American Cancer Society Grant I.C. 82, Kidney Foundations of Michigan, NIH Grant AI11923-01, and Children's Leukemia Foundation of Michigan.

Received 6/14/74. Accepted 9/25/74.