This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Misra, N. C. Articles by Roberts, D. Search for Related Content PubMed PubMed Citation Articles by Misra, N. C. Articles by Roberts, D.

Inhibition by 4'-Demethyl-epipodophyllotoxin 9-(4,6-O-2-Thenylidene-ß-D-glucopyranoside) of Human Lymphoblast Cultures in G₂ Phase of the Cell Cycle¹

Laboratories of Pharmacology, St. Jude Children's Research Hospital, Memphis, Tennessee 38101

4'-Demethyl-epipodophyllotoxin 9-(4,6-O-2-thenylidene-ß-D-glucopyranoside) is a semisynthetic derivative of podophyllotoxin with oncolytic activity against a variety of neoplasms. Unlike the parent compound and other derivatives, which cause metaphase arrest, 4'-Demethyl-epipodophyllotoxin 9-(4,6-O-2-thenylidene-ß-D-glucopyranoside) apparently blocks the entry of CCRF-CEM cells into mitosis by inhibiting cells in the G₂ phase of the cell cycle. The inhibition of precursor incorporation into DNA, RNA, and protein, if observed, was delayed and probably secondary to inhibition of cells in the G₂ phase of the cell cycle.

¹ Supported by USPHS Cancer Research Grant CA-08480, Research Project Grant CA-12732 from the National Cancer Institute, and ALSAC.

² Karnofsky Fellow at St. Jude Children's Research Hospital.

Received 7/29/74. Accepted 10/ 8/74.

This article has been cited by other articles:

				P. R. Andreassen, F. B. Lacroix, and R. L. Margolis Chromosomes with Two Intact Axial Cores Are Induced by G2 Checkpoint Override: Evidence That DNA Decatenation Is not Required to Template the Chromosome Structure J. Cell Biol., January 13, 1997; 136(1): 29 - 43. [Abstract] [Full Text] [PDF]