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Proliferation-dependent Cytotoxicity of Anticancer Agents: A Review¹

Luke van Putten

Section of Cancer Biology, Division of Radiation Oncology, Mailinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, Missouri 63110 [F. V.], and Radiobiological Institute TNO, 151 Lange Kleiweg, Rijswijk (ZH), The Netherlands [L. V.]

One of the factors of importance in determining the killing of mammalian cells following exposure to a variety of anticancer agents is the proliferative state of the cell population. Generally, proliferating cells are much more sensitive to anticancer agents than are nonproliferating cells. In this review, the cellular aspects of this differential sensitivity are discussed with the hemopoietic stem cell population and tissue culture cells as the focus for the analysis. This phenomenon is not only of concern to the cell biologist but also has implications with regard to scheduling of anticancer agents against human tumors.

¹ This work was supported by USPHS Grant CA-13053 from the National Cancer Institute and was part of a program of the EORTC Screening and Pharmacology Group.

Received 2/24/75. Accepted 5/22/75.

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