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Fast- and Slow-Growing Transplantable Tumors Derived from Spontaneous Mammary Tumors of the DBA/2 Ha-DD Mouse¹

Department of Experimental Therapeutics and Grace Cancer Drug Center, Roswell Park Memorial Institute, New York State Department of Health, Buffalo, New York 14263

³ To whom reprint requests should be sent.

Nineteen transplantable tumor lines were established from individual spontaneous mammary tumors of the DBA/2 Ha-DD mouse. Of these lines, 5 were classified as fast growing, 8 as medium growing, and 6 as slow growing, based on the time required for the tumors to reach a size of 10 mm in average diameter and on the average survival time of tumor-bearing syngeneic hosts. The relative differences in rate of growth among 5 of these lines remained stable during 11 to 19 transplant generations. In DBA/2J mice, a slow-growing and a fast-growing tumor line were cross-immunogenic. The differences in growth rate between these 2 tumor lines were not primarily related to differences in immunogenicity since they were not abolished in preirradiated hosts. The growth of cell populations from these 2 tumor lines in culture was comparable; however, cells from the fast-growing line had a plating efficiency about 4 times higher than those from the slow-growing line.

¹ Supported in part by Core Program Grant CA-13038 and Project Grant CA-15-142 from the National Cancer Institute, USPHS.

² On leave from the Department of Pathology, Cancer Institute, Hokkaido University School of Medicine, Sapporo, Japan. The work reported in this paper was undertaken during the tenure of a Research Training Fellowship awarded by the International Agency for Research on Cancer, WHO.

Received 3/14/75. Accepted 6/12/75.