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Sequential Analysis of Transplantable Hepatocellular Carcinomas¹

Department of Pathology, New York University School of Medicine, New York, New York 10016 [F. F. B., S. R. W.]; Laboratory of Microbial Immunity, National Institute of Arthritis and Infectious Disease, NIH, Bethesda, Maryland 20014 [R. A.]; and Department of Pathology, University of California School of Medicine, San Diego, California 92037 [S. S.]

In a previous study multiple characteristics of chemically induced primary hepatocellular carcinomas were described and examined during the initial transplant generations. The present communication reports on these characteristics in subsequent transplant generations followed over a 2-year period. In almost all instances the growth rate, morphology, chromosome composition, and plasma protein and -fetoprotein synthesis of individual tumors have remained relatively constant. However, one spontaneous subline of a diploid tumor demonstrated a sudden extensive rearrangement of its chromosomes simultaneous with a significant acceleration of growth rate. Despite karyotypic evolution, it retained the functional chracteristics of diploid tumors, producing no plasma protein or -fetoprotein.

¹ These studies were supported by Grant CA-12141, NIH, and Contract E72-3258, National Cancer Institute.

Received 10/ 3/74. Accepted 7/11/75.