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Relationship of Plummer-Vinson Disease to Cancer of the Upper Alimentary Tract in Sweden¹

Department of Oncology, University Hospital of Umeå, 901 85 Umeå, Sweden

Sideropenic anemia with epithelial lesions (Plummer-Vinson syndrome) was previously very common among women in northern Sweden. The incidence of this condition is decreasing, however, because of between nutrition and improved health care. Plummer-Vinson syndrome as a sequela of previous sideropenic anemia still influences the pattern of hypopharyngeal and oral cancer in northern Sweden, where the female/male ratio in these diseases is remarkably high and where cancer in the postcricoid part of the hypopharynx is relatively common. In Sweden as a whole, a decreasing trend in the incidence of hypoharyngeal cancer in women can be demonstrated, which is probably due to diminshed prevalence of Plummer-Vinson syndrome.

¹ Presented at the conference on Nutrition in the Causation of Cancer, May 19 to 22, Key Biscayne, Fla.