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Nutrition and Tumor Immunity: Divergent Effects of Antitumor Antibody¹

The Thorndike Laboratory of the Harvard Medical School, Beth Israel Hospital, Boston, Massachusetts 02115

Nutritional deficiency reduces antibody synthetic capacity. Antibody directed against tumor antigens, however, may serve either to heighten tumor immunity, as in antibody-dependent cellular cytotoxicity, or to diminish host resistance to cancer growth by "blocking" cellmediated tumor immunity. Diets made deficient in specific amino acids are inimical to tumor growth, apparently through reduction of synthesis of blocking antibody. Thus, where tumor immune function is involved, complex and possibly paradoxical effects of nutritional status on tumor growth can be predicted.

¹ Presented at the Conference in Nutrition in the causation of Cancer, May 19 to 22, 1975, Key Biscayne, Fla.

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