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Hormones, Nutrition, and Cancer¹

Cancer Center, Inc., Northeast Ohio, Case Wester Reserve University School of Medicine, Cleveland, Ohio 44106

The effect of obesity o steroid metabolism in women with breast and uterine cancer have been considered. Obesity may increase plasma estrone by two mechanisms, a higher rate of secretion of the estrone precursor, androstenedione, and a higher rate of conversion of androstenedione to estrone. Obesity may alter routes of metabolism of androgens and estrogens. The excretion of specific urinary metabolites can therefore be altered by obesity alone. Thus, steroid indices of relative cancer risk or responsiveness must be constructed with due attention to obesity, one of many important variables.

¹ Presented at the Conference on Nutrition in the Causation of Cancer, may 19 to 22, 1975, Key biscayne, Fla.