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Estrogen Receptors in Hormone-dependent Breast Cancers¹

Ben May Laboratory for Cancer Research, University of Chicago, Chicago, Illinois 60637

The determination of estrogen receptors (estrophilin) in human breast cancers, both primary and metastatic, can furnish information useful to the clinician in his choice of the optimal therapy for the individual patients with advanced disease. Of patients with significant tumor estrophilin levels, most, but not all, will respond favorably to endocrine therapy. Women whose cancers lack sufficient amounts of estrophilin have little or no chance of benefit from endocrine ablation or hormone administration and probably should be treated directly by alternative types of therapy.

¹ Presented at the Conference on Nutrition in the Causation of Cancer, May 19 to 22, 1975, Key Biscayne, Fla. These investigations were supported by USPHS Contract NO1 CB-43969 an Grant 5 PO1 Ca-14599 from the National Cancer Institute.

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