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Comments on the Epidemiology of Large Dowel Cancer¹

Department of Pathology, Louisiana State University Medical Center, New Orleans, Louisiana 70112

Available evidence strongly suggests that there are at least two epidemiological subentities of large bowel cancer. Tumors of the intermediate portions display a socioeconomic gradient not observed for cancer of the cecum or lower rectum. Dietary factors are the most plausible etiological candidates. High-fat intake may be a prominent factor, but other dietary constituents could be relevant and may be studied in populations in which stomach and large bowel cancer are infrequent. The epidemiological usefulness of precursor lesions is emphasized.

¹ Presented at the Conference on Nutrition in the Causation of Cancer, May 19 to 22, 1975, Key biscayne, Fla. work supported by Contract NO1-CP-53521, National Cancer Istitute, NIH, USPHS.