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Microcytotoxicity Assays of Tumor Immunity in Patients with Bronchogenic Carcinoma Correlated with Clinical Status¹

Department of Surgery, University of Kansas Medical Center, and College of Health Sciences, Kansas City, Kansas 66103

Peripheral blood lymphocytes from patients with bronchogenic carcinoma were tested in microcytotoxicity assays against cultured bronchogenic cancer cells, other types of tumor cells, and skin fibroblasts. Lymphocytes from patients who were postresection with no clinical evidence of residual or recurrent tumor were more frequently toxic against bronchogenic carcinoma than were lymphocytes from normal donors or from patients with clinically evident disease. Lymphocytes from patients with minimal or no tumor were more frequently toxic against bronchogenic cancer than against skin fibroblasts. Serum samples from a few patients rendered lymphocytes toxic for bronchogenic cancer cells, but this serum activity could not be correlated with the patient's clinical status.

¹ This study was supported by USPHS Grant R01-CA12681-01 and by a General Research Support Grant from the University of Colorado.

² To whom requests for reprints should be sent, at Department of Surgery, University of Kansas Medical Center and College of Health Sciences, 39th and Rainbow Boulevard, Kansas City, Kans. 66103.

Received 7/15/75. Accepted 8/12/75.