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Replication of an Avian Myxovirus in Tumor Cell Cultures Obtained from Effusions of Mammary Carcinoma Patients¹

Division of Oncology, Department of Medicine [H-J. I., C. S.], and Division of Experimental Microbiology, Institute of Medical Microbiology [J. L.], University of Zürich, 8091 Zürich, Switzerland

In view of the possible use of viruses for the immunotherapy of breast cancer, the replication of a strain of fowl plague virus was studied in the tumor cells of 11 mammary carcinoma patients with malignant effusions. The tumor cells were obtained by centrifugation on iodamide solutions, then cultured in vitro, and infected by a fowl plague virus previously adapted to grow in a mammary carcinoma cell line. Virus multiplication was observed in all cases, a prerequisite for the use of autologous viral oncolysates for immunotherapy in mammary carcinoma patients.

¹ Supported by the Julius Müller Foundation for Cancer Research, Zürich, Switzerland; the Ludwig Institute for Cancer Research, Zürich Branch; and the Hans Gröber Stiftung, Vaduz, Liechtenstein.

² Present address: Medizinische Universitätsklinik, Bonn, West Germary.

³ To whom requests for reprints should be addressed, at Division of Oncology, Department of Medicine, University of Zürich, 8091 Zürich, Switzerland.

Received 7/ 7/75. Accepted 8/26/75.