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Interval Effect of ß-Irradiation and Subsequent 4-Nitroquinoline 1-Oxide Painting on Skin Tumor Induction in Mice¹

National Cancer Center Research Institute, Tsukiji, Chuo-ku, Tokyo 104, Japan

Skin tumors were produced in female ICR mice by ⁹⁰Sr-⁹⁰Y ß-irradiation and subsequent 4-nitroquinoline 1-oxide painting. The doses were chosen so as to produce no tumors with a single agent alone; the interval between two treatments ranged from 11 to 408 days. The tumor induction rate was found to be at almost the same level (average, 12.4%) for each interval. The results indicate the persistence of the latent carcinogenic alterations in the ß-irradiated mouse skin.

¹ Supported by a subsidy for cancer research from the Ministry of Health and Welfare and grants in aid from the Ministry of Education, Japan.

² On leave from Keio University Medical School.

Received 6/13/75. Accepted 8/25/75.