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Etiological Factors, Stages, and the Role of the Foreign Body in Foreign Body Tumorigenesis^1: A Review

Department of Microbiology, Medical School, University of Minnesota, Minneapolis, Minnesota 55455 [K. G. B., L. C. B., I. B.], and Department of Veterinary Biology, College of Veterinary Medicine, St. Paul, Minnesota 55101 [K. H. J.]

Attempts were made to analyze the process of foreign body (FB) tumorigenesis and to identify etiologically significant factors by correlating information in the literature and recent experimental data from our laboratory. It appears that the process of FB tumorigenesis is dependent on a sequence of specific conditions as expressed by the following criteria: (a) cellular proliferation and tissue infiltration during acute FB reaction; (b) fibrosis of the tissue capsule surrounding the FB; (c) quiescence of the tissue reaction, i.e., dormancy and phagocytic inactivity of FB-attached macrophages; and (d) availability of a FB surface for direct contact with clonal preneoplastic cells. There is no indication that the initial acquisition of neoplastic potential and the determination of specific tumor characteristics are based on direct physical or chemical reaction between cells and the FB. These etiological key events occur presumably in mesenchymal stem cells associated with the microvasculature no later than during the acute stage of FB reaction and certainly long before clonal descendants of these cells are first found in contact with the FB surface. In fact, there is reason to assume that cells with neoplastic determination may be present in normal tissue prior to the introduction of a FB and that the FB would only create the conditions required for stepwise preneoplastic maturation.

¹ Supported by USPHS Grant CA 10712 from the National Cancer Institute.

Received 6/25/74. Accepted 9/23/74.

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