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Glomerular Immune Complex Deposits Associated with Mouse Mammary Tumor¹

Department of Pathology and Cancer Research Center, Columbia University, College of Physicians and Surgeons, New York, New York 10032

Adult Paris R-III mice with localized mammary tumors were found to have subendothelial glomerular immune complex deposits by electron microscopy and immunofluorescence. In addition to IgG and B-1-C, the glomeruli contained antigenic material that reacted with an antiserum to mouse mammary tumor virus. These findings support the hypothesis that many animals with congenitally or neonatally induced virus-related tumors are not immunologically tolerant to the oncogenic virus.

¹ Supported in part by Center Grant CA-13696-02 from the National Cancer Institute.

Received 8/23/74. Accepted 10/11/74.