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A Carcinofetal Antigen Located on the Membrane of Cells from Rat Intestinal Carcinoma in Culture¹

Laboratory of Experimental Medicine [F. M., S. K.], Institut National de la Santé et Recherche Médicale [M. M.], and Centre G. F. Leclerc [M. B.], Faculty of Medicine, Boulevard Jeanne d’ Arc, 21000 Dijon, France

Heteroantisera were produced in rabbits by immunization with cultivated cells from rat intestinal carcinomas. The sera were made specific by in vivo absorption in syngeneic rats. On immunofluorescence, these sera recognized a membrane-associated antigen common to five different intestinal carcinomas and to fetal intestine. The antigen was not detected in noncancerous adult intestine, nonintestinal fetal tissues, or three nonintestinal tumor cell lines.

¹ This investigation was supported by Research Grants CA 401 and 71-10704 from the Institut National de la Santé et Recherche Médicale (INSERM).

Received 8/ 5/74. Accepted 9/27/74.