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Morphological Basis for the Cytolytic Effect of Vinblastine and Vincristine on Cultured Human Leukemic Lymphoblasts¹

Sidney Farber Cancer Center and Harvard Medical School, Boston, Massachusetts 02115

Exposure of human leukemic lymphoblasts in suspension cultures to low concentrations of vinblastine and vincristine results in alterations in cell shape and leads to the formation and release of a large number of membrane-lined vesicles from the cytoplasm. Separation of these vesicles from peripheral cytoplasm is effected through alignment and fusion of small vacuoles. Similar vesicle formation is seen neither in fibroblasts exposed to vinblastine nor in lymphoblasts exposed to bleomycin or adriamycin. Possible relation of this phenomenon to vinblastine- and vincristine-induced cytotoxicity, spherocytosis, and thrombocytosis is discussed.

¹ These studies were supported by National Cancer Institute Grant C-6516.

Received 9/20/74. Accepted 11/14/74.